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(98) further showed that the FP extracellular matrix regulates the DC IL-10/IL-12 balance via a TLR2-dependent pathway, linking innate and adaptive immunity

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Low levels cause protein synthesis to be less effective, resulting in slow muscular recovery and less growth

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Mechanistically, intra-articular AOD-9604 may stimulate synovial fibroblast proliferation or reduce inflammatory cytokine production in the synovial microenvironment, though direct effects on cartilage are unclear

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