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Active site loops conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426

5-Amino-1MQ is an oral NNMT (nicotinamide N-methyltransferase) inhibitor that works by blocking an enzyme that depletes cellular NAD+ and SAM

No matter which design you prefer, this got me thinking further still

doi: 10.3389/fpubh.2025.1598092 6 LiuMWeiSYangXLuZZhangWMensahEet al
