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These studies are important for doctors, patients, and public health planners alike, as they determine how the drug will be utilized across populations

Oral semaglutide 25mg in adults with overweight or obesity (OASIS 4)

It is a triple GIP/GLP-1/glucagon receptor agonist approved for obesity

To date, two incretins, glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), have been identified

Because the majority of the -cells do not express GLP-1R, and also because GLP-1 inhibits glucagon secretion even in T1D patients with low insulin pancreatic reserve, the mechanism by which GLP-1 decreases glucagon secretion is still a matter of debate [15]