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On the other hand, delay in diagnosis and adequate treatment, nonadherence to therapy, and, in the worst case, LN recurrence are factors that would lead to further nephron loss and further progression of CKD ( Classical nephroprotective treatment SLE patients have a higher mortality rate than the general population, with infections, cardiovascular (CV) complications, and especially renal failure as the leading causes of death ( Moreover, glucocorticoid therapy, mainly when high doses are used for a prolonged period, increases bone loss, incidence of CV events and infections, risk of malignancies, especially non-Hodgkins lymphoma, lung, and skin cancer ( Pregnancy in patients with LN is associated with increased maternal complications compared to the healthy population ( The amount of proteinuria is a decisive factor in the prognosis of patients with LN

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Masters CL, Bateman R, Blennow K, Rowe CC, Sperling RA, Cummings JL