once-weekly semaglutide in persons with obesity and knee osteoarthritis Wegovy Reduced Pain From Once-Weekly Semaglutide in Persons with
Description
[9] Drugs.com
Patients with naturally high baseline leptin and peptide YY levels may respond at lower doses, while those with resistant hunger signals may need to advance more quickly

PlexusDx recommends timing any psychosocial support to begin 23 weeks before you start tapering, ensuring you have emotional tools in place as biological appetite signals intensify

This means your body responds less effectively to non-bioidentical hormones, and they also come with a greater risk of side effects
No, fasting is not required