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However, healthcare providers would need to be careful about potential drug interactions and how semaglutide may influence the effectiveness of other medications

High dropout rates in obesity and diabetes trials highlight tolerability issues, which may be further compounded in psychiatric populations where comorbid anxiety, cognitive impairment, or poor illness insight can interfere with consistent medication use

Multiple biosimilars launched in 2025 following settlement agreements that established royalty-bearing access

Observational studies and smaller clinical trials have examined men with obesity and type 2 diabetes treated with GLP-1 receptor agonists, including semaglutide

Generic manufacturers who attempted to replicate the abuse-deterrent properties through alternative polymers were unable to secure FDAs abuse-deterrent labeling, which meant their label explicitly disclaimed the deterrent properties that Purdue claimed a commercial disadvantage that depressed their market share even after launch