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For example, in a mid-stage human study, people taking higher doses (up to 12mg) lost an average of 24% of their body weight over 48 weeks, which is about 58 pounds for some

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A comprehensive literature search was conducted across the PubMed, Embase, and Google Scholar databases for peer-reviewed articles published from inception through June 15, 2026, focusing on the landmark SURPASS, SURMOUNT, and SUMMIT trial programs, relevant cardiorenal post hoc analyses, emerging body recomposition trials, and real-world cohort-switching protocols