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It is capable of crossing the blood-brain barrier when administered peripherally, reaching the paraventricular nucleus of the hypothalamus, where MC4R signaling coordinates both food intake and energy expenditure

increased cortisol levels were observed in both healthy humans and type 1 diabetes patients to whom GLP-1 had been administered peripherally [76]

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Reddys Laboratories, and Lupin are already working on GLP-1-based therapies, preparing for increased demand once patents expire in 2026 in various global markets