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In participants with obesity or overweight, withdrawing tirzepatide led to substantial regain of lost weight, whereas continued treatment maintained and augmented initial weight reduction [75]

Statistically significant reduced incidence seen across multiple large cohorts For this analysis, the researchers looked at health records from 111,646 women ages 45 to 80 with a body mass index (BMI) of 25 or above (the overweight threshold) who had breast imaging and a documented outcome in the Penn Medicine EHR between January 2022 and June 2025

Bartels AL, Willemsen ATM, Doorduin J, de Vries EFJ, Dierckx RA, Leenders KL

Carnitine plays an essential role in the way that mitochondria use fats for fuel, and the study showed that mice deficient in a carnitine transporter, SLC25A45, didnt lose weight as easily on a GLP-1 RA medication.[ref] Related article: Carnitine genes GLP-1 Beyond Weight Loss: Heart Disease, Alzheimers, Cancer, and Immunity Recent studies show that the benefits of GLP-1 RA medications extend beyond weight loss

These medications treated Type 2 diabetes for nearly two decades before becoming household names