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In the U.S., for example, only 2% of the obese adult population were historically treated with anti-obesity drugs, due to a combination of lack of clarity about the role and value of pharmacotherapies (which were also less effective and sometimes with greater side effects than the recently launched treatments), limited insurance coverage and resulting out-of-pocket costs12

Gastrointestinal tract is an important connector between food intake and body weight, it senses basic tastes in a similar manner as the tongue

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