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Exendin(9-39)Amide Is an Antagonist of Glucagon-Like Peptide-1(7-36)Amide in Humans

doi: 10.1007/s40256-024-00673-1 25 Fonseca-CorreaJICorrea-RotterR

Abbreviations CNRC: Childrens Nutrition Research Center FFM: Fat-free mass GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide-1 GPR: Glucose production rate HISI: Hepatic insulin sensitivity index IGI: Insulinogenic index iGLP-1: Intact GLP-1 MIGHTY: Metformin Influences Gut Hormones in Youth NGT: Normal glucose tolerance NIH: National Institutes of Health PYY: Peptide YY R a : Rate of appearance WBISI: Whole-body insulin sensitivity index References Zeitler P, Hirst K, Pyle L et al (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes

TRIUMPH-4 demonstrated 28.7% average weight loss at 68 weeks (December 2025)

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