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S., Piscopo, K

GLP-1RAs also reduce food intake by modulating appetite-regulating pathways in the brain, resulting in weight loss (Koide et al., 2025) (see Figure 1)

14.9% average weight loss vs 22.5% vs 28.7%

An optogenetic stimulation of GLP-1Rs in habenular circuits was also shown to abolish nicotine reward and decrease nicotine intake in mice 109