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If you develop signs of methotrexate toxicitymouth sores, severe diarrhea, or elevated liver enzymesyour provider may need to hold or reduce methotrexate while your body stabilizes, even if semaglutide dosing is otherwise appropriate

Metabolic dysfunction

It works by mimicking a natural hormone (GLP-1) in your body that helps regulate insulin, control blood sugar, and slow down digestion

Additionally, these treatments moderate gastric emptying and decrease food consumption, assisting patients in curbing their appetite and facilitating weight loss

However, the gastrointestinal side effects of Wegovyparticularly nausea, vomiting, and diarrhoeacan potentially lead to dehydration if fluid intake is inadequate