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Note: This article offers general information and does not replace professional medical advice

The endogenous GLP-1 hormone is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), resulting in a half-life of less than 5 min in the circulation (2, 3)

GLP-1 Costs Without Medicaid Coverage Retail prices for GLP-1 medications in 2026: If Medicaid wont cover your GLP-1: TrumpRx the federal direct-purchase portal launched in 2025

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The key is to respond early by tightening meal structure, increasing protein, and checking in with your provider if weight starts to creep up