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Evidence-Based Non-Drug Options That Work With Medi-Cal limiting weight-loss GLP-1 coverage, lifestyle medicine becomes the foundation: Plant-forward nutrition to improve insulin sensitivity Resistance training to protect lean mass and metabolism Sleep & stress care to reduce cortisol and glucose variability These strategies are core to our metabolic services: Prediabetes Reversal (12 weeks) Sleep Apnea & Weight care (HSAT + CPAP when indicated) MASLD (fatty liver) care All are designed to improve A1C, BP, lipids, and weight without relying solely on medications

For heart failure or chronic kidney disease, the American Diabetes Association generally recommends SGLT2 inhibitors as first-line agents, with GLP-1 receptor agonists considered for their benefits on atherosclerotic cardiovascular disease, glycemic control, and weight management, or when SGLT2 inhibitors are not appropriate

Nicotinamide riboside augments the aged human skeletal muscle NAD(+) metabolome and induces transcriptomic and anti-inflammatory signatures

A small, two-week clinical trial evaluating GLP-1R antagonism for the treatment of postbariatric hypoglycemia did not change bodyweight in participants, although interpretation of bodyweight changes in this population is challenging (96)

Last reviewed: June 9, 2026 Last updated: June 9, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations