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High-profile celebrities have publicly discussed using GLP-1 receptor agonists for weight management, sparking global interest in semaglutide and tirzepatide

While GLP-1 drugs have been used for diabetes treatment for decades, their use for weight loss is relatively recent

This innovation addresses a long-standing barrier in obesity care: the reliance on injectable therapies

After a maximum 12-week screening phase, an anticipated 1840 patients in each trial are randomized (1:1) to semaglutide or placebo for 156 weeks (104-week main treatment phase and 52-week extension)

With semaglutide patent expiry expected next year, competitive entry could pull prices down from current ~1726k/month and accelerate adoption