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Following GLP-1RA treatment, SCFAs, such as butyrate and propionate, are elevated [9, 10]

In addition, bariatric surgery increased intestinal hormones such as GLP-1 and peptide YY (PYY) (9) and changed the composition of gut microbiota (10) and bile acids (BAs) (11), which all enhanced GLP-1 responses in obese individuals with T2D

Beyond metabolic regulation, GLP-1RAs exhibit potent anti-inflammatory and immunomodulatory properties that contribute to their therapeutic efficacy in MASLD

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It is worth understanding that brand-name semaglutide is manufactured under strict FDA oversight with standardized concentrations, while compounded versions are produced by pharmacies operating under different regulatory frameworks