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glp 1 anhedonia GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP-1a: Going beyond Traditional Use
Description
36 GLP-1R GLP-1R, a member of the GPCR family, exhibits specific affinity for GLP-1
![glp 1 anhedonia GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP-1a: Going beyond Traditional Use](https://www.mdpi.com/ijms/ijms-23-00739/article_deploy/html/images/ijms-23-00739-g010.png)
Treatment of primary neonatal mouse cardiomyocytes with liraglutide increases cAMP formation and reduces apoptosis, as indicated by inhibition of TNFa induction of caspase 3 activity [614]
![glp 1 anhedonia GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP-1a: Going beyond Traditional Use](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41591-025-04124-5/MediaObjects/41591_2025_4124_Fig1_HTML.png)
These drugs were initially developed for the treatment and/or management of diabetes, but scientists thought this drug could be a direct cure for obesity as well
![glp 1 anhedonia GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP-1a: Going beyond Traditional Use](https://i.ytimg.com/vi/6Lhf6O-H_NA/hq720.jpg?sqp=-oaymwE7CK4FEIIDSFryq4qpAy0IARUAAAAAGAElAADIQj0AgKJD8AEB-AHOBYACgAqKAgwIABABGHIgUihEMA8=&rs=AOn4CLBjLdLQuPE19Zb2_O_HbEdSVkmiyQ)
Neuropsychopharmacology 31 , 12031211 (2006)
Medicina (Kaunas) 2019;55(6):233
![glp 1 anhedonia GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP-1a: Going beyond Traditional Use](https://media.springernature.com/m685/springer-static/image/art%3A10.1134%2FS0022093025050023/MediaObjects/10893_2025_8887_Fig1_HTML.png)