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Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect

JACC Cardiovasc Imaging 11:577585

One suppresses appetite without causing aversion [like nausea], and the other mediates most of the aversion effect. But Dr

By activating these receptors, GLP-1 exerts various biological effects in the central nervous system, including promoting neuroprotection and neurogenesis

Summary: There is no formal contraindication to taking berberine and Wegovy together, but you must consult your GP or prescribing clinician before combining them due to potential risks including hypoglycaemia and intensified gastrointestinal side effects
