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How Gastric Sleeve Surgery Affects Digestion and the Nervous System Gastric sleeve surgery removes approximately 7580% of the stomach, altering vagal nerve signalling, reducing ghrelin, and increasing GLP-1 and PYY, all of which affect digestion and satiety

Clearly positive for patients, especially those with high out-of-pocket costs
Trulicity patients have sued Eli Lilly, and a federal group claim has been created

Yet pre-existing leptin receptor resistance often persists, creating a physiological environment that actively resists further weight loss
In response to long term caloric restriction we adapt - we reduce heat production (thermogenesis) by changing our hormones and reducing the number of constantly active cell channels we express
