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High cardiovascular risk: Patients with multiple risk factors (diabetes, hypertension, high cholesterol, smoking history, family history) likely benefit, though direct trial evidence in lower-risk populations is less extensive

Once acid reflux stabilizestypically within 4-6 weeks of starting or after dose adjustmentsmost patients resume their therapy progression without further digestive complications

95% CI, 0.78-0.85) reduced risk for cardiovascular events compared with sulfonylureas users

Critical Reviews in Food Science and Nutrition , 57 (14), 31543163

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