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While weight loss is a potential side effect of metformin, it is not guaranteed for everyone who takes the medication

However, rapid weight loss often comes with unwanted side effects: muscle loss (up to 20-60% of total weight lost) and sagging skin on areas like the arms, neck, or belly

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The study, published in Nature Health , covers more than half a decade of posts from nearly 70,000 Reddit users and highlights two main classes of symptoms that warrant further study: reproductive symptoms, including irregular menstrual cycles, and temperature-related complaints, such as chills and hot flashes