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Description
GLP-1s: Lower blood sugar Reduce appetiteso you eat less and feel fuller Promote healthy weight loss Improve metabolism Lower whole-body inflammationincluding that which affects your joints GLP-1s Target Both Metabolic and Inflammatory Pathways Recent research shows that GLP-1 medications can: Lower levels of inflammatory cytokines like TNF-alpha, IL-6, and IL-1 Restore a healthier gut microbiome and calm immune reactions Reduce fat-driven inflammationwhy losing just 510% of body weight improves autoimmune diseases Reverse insulin resistancea key link between metabolic and autoimmune disease Reduce oxidative stress, protecting organs and joint cartilage GLP-1s in RA, PsA, OA, and More: Evidence and Results Rheumatoid Arthritis Obesity increases RA risk and severity

Department of Medicine and Optometry, eHealth Institute, Linnaeus University, Kalmar, Sweden INTRODUCTION Glucagon-like peptide-1 (GLP-1) receptor agonists and GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists have demonstrated efficacy in achieving and maintaining weight loss

JW: Investigation, Supervision, Writingreview and editing

Wegovy (semaglutide) is a GLP-1 receptor agonist (GLP-1 RA) that mimics GLP-1the fullness hormonethat causes you to start feeling full as you eat

This hormonal environment increases ghrelin (the hunger hormone) while reducing leptin sensitivity, making you feel hungrier despite adequate calorie intake
