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This effect is likely driven by the prolonged circulating half-lives of long-acting and ultra-long-acting GLP-1RAs, such as semaglutide (via fatty acid acylation) and dulaglutide (via Fc fragment fusion), which maintain sustained GLP-1 receptor stimulation and enhance intestinal motility, thereby increasing diarrhea risk

Karen Plymel, Functional Medicine Expert GLP-1 Agonists for Medical Weight Loss: Safety, Efficacy, and Cost Considerations In the ever-evolving landscape of weight loss treatments, GLP-1 agonists have garnered attention for their potential to help individuals manage obesity and related conditions

Bottom line: Leg cramps during Mounjaro treatment are usually a manageable secondary effect of dehydration or electrolyte loss and can often be resolved with better hydration and mineral support

By incorporating such programs, they may reduce the long-term costs associated with chronic conditions like diabetes and cardiovascular diseases, improve patient adherence and satisfaction, and ultimately enhance overall population health

[DOI] [PubMed] [Google Scholar] Gallwitz B, Ropeter T, Morys-Wortmann C, Mentlein R, Siegel EG, Schmidt WE
