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A phase 1b clinical trial in Chinese individuals using a MAD study design shows a mean weight loss at 12 weeks of 11.7% at 9 mg, and 9.5% over 16 weeks at 10 mg, versus 1.8% and 3.3% in those who received placebo, respectively (86)

Legg M., Stahlman S., Chauhan A., Patel D., Hu Z., Wells N

doi: 10.1016/S0140-6736(21)00213-0 34 JensterleMFerjanSVovkABattelinoTRizzoMJaneA

This leads to the upper lip overhanging the lower lip and thus making the corners of the mouth deeper, which results in the persistent presence of saliva and consequent irritation of the skin

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