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However, there is extensive mechanistic, toxicological, and epidemiological evidence of the harmful effects of the numerous toxicants and carcinogens that are formed upon the thermal degradation of sugars and sweeteners in tobacco and nicotine products that are heated/combusted and used via inhalation

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In fact, drinking this much or more "could be harmful, both in precipitating potentially dangerous hyponatremia and exposure to pollutants, and also in making many people feel guilty for not drinking enough," he wrote in his 2002 review for the American Journal of PhysiologyRegulatory, Integrative and Comparative Physiology