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However, our estimates in patients with diabetes align with the reported estimates from the randomized trials

Some evidence of delayed gastric emptying during the first hour of the meal test was apparent with liraglutide 3.0 mg (a nonsignificant trend with 1.8 mg was observed), in agreement with results from previous trials with liraglutide 1.8 mg in T2DM

A meta-analysis of GLP-1RA CVOT showed that treatment with GLP-1RA reduced the risk of developing a composite kidney outcome including new-onset MA by 21% compared to placebo (HR 0.79, 95% CI 0.73-0.87), with only ELIXA and EXSCEL not achieving significant benefit [11]

The ability of histamine to signal in this fashion raises the potential for histaminergic neurons to prime other neurons responsiveness to additional incoming (metabolic) stimuli during waking hours when histaminergic tone is highest

Mead, R