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Description
Retrieved Mar
The SURPASS-CVOT trial, where dulaglutide at the dose of 1.5 mg/week or at the highest tolerated dose, is the comparator, has a distinctive design from the other trials: the primary endpoint is the time to the first manifestation of any major adverse CV event (MACE), defined as myocardial infarction, stroke or CV death
It also explains retatrutide's unique side effect (dysesthesia) not seen with tirzepatide
After 2 to 3 weeks at a stable dose, many people experience minimal or no side effects
It is used in research settings to investigate combined GIP/GLP-1 receptor agonism and downstream effects relevant to metabolic regulation
