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Description
In clinical trials, patients using semaglutide 2.4 mg weekly achieved average weight loss of 1215% of body weight over 68 weeks (approximately 26-33 lbs for a 220-lb person), substantially greater than placebo

Others may not tolerate 7.2mg well enough for the possible extra benefit to be worthwhile

Zhu CS, Kwan EA, Williams GM, et al

You may experience these effects more strongly when your healthcare provider increases your dose
The kidney and general tissue proteolysis handle metabolism
