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There is no current evidence that retatrutide reduces cardiovascular events

This results in improved blood sugar control for people with type 2 diabetes

In Latin America, where obesity rates have grown faster than in other parts of the world, the drug remains unaffordable for the bulk of the population

A study published last summer by JAMA Oncology looked at GLP-1 use and 14 obesity-related cancers and found that while the weight-loss drug lowered the risk of most cancers, there was a nonsignificant increased risk of kidney cancer particularly among people younger than 65

Additionally, the substitution of arginine at positions 2 and 13 with 2-aminoisobutyric acid (Aib) increases its resistance to DPP-4 and enhances its ability to bind to albumin, thereby improving its stability and half-life