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However, due to the limited scope of small-scale experiments (e.g., one concentration, one time point exposure), this is not always done, leading to great uncertainties on the predictive value of the observed metabolic alterations

Introduction Recent proton magnetic resonance spectroscopy (MRS) studies in schizophrenia (SZ) have shown altered GABAergic ( In this study, GABA, glutamate (Glu), glutamine (Gln), lactate, and the ratio of Gln/Glu were quantified from five brain regions [anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), centrum semiovale (CSO), thalamus (Thal), and hippocampus (HP)] in each of the three groups: participants with schizophrenia (SZ), first-degree relatives (FDR), and healthy controls (HC)