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(2013) Functional analysis of novel variants in the organic cation/ergothioneine transporter 1 identified in Singapore populations

These changes lead to altered oxidative phosphorylation, as well as increased oxidative stress, calcium influx, inflammation, apoptosis, and mitochondrial dysfunction, being all of them physiopathological processes commonly observed in aging and its associated diseases (McCully, 2018)

Systemically aminoglycoside administration preferentially induces cochlear hair cell death and results in irreversible hearing loss