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Although an increase of gut wall thickness can affect gut fluid dynamics, a meta-analysis was not carried out for this parameter even though it showed an approximately twofold increase in active CD patients compared to healthy volunteers in the few studies encountered [78, 80, 81, 93, 158]

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However, to build a CD population with all relevant known physiological differences in intestine and other organs, we had to incorporate relative changes in each parameter into the population library files within the simulator, based on our analysis of the systems parameters described in the previous section