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Kumaran S, Panneerselvam KS, Shila S, Sivarajan K, Panneerselvam C: Age-associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: role of carnitine and lipoic acid

One of the proposed mechanisms for the onset of hand-foot syndrome induced by traditional chemotherapy drugs is excretion of the chemotherapy agents via the sweat glands.11 This mechanism could not however be demonstrated for hand-foot skin reaction associated with multikinase inhibitors, as significant levels of sorafenib were not detected in the sweat of these patients.19 In this case, the authors proposed leakage of the drug through capillaries damaged by subclinical trauma as the pathogenic mechanism

For mitochondrial disease in general, pathogenic mutations have been reported in all 37 mtDNA genes and more than 254 nDNA-encoded genes [16]

Phenethylamines: The phenethylamines-related compounds that have been identified by NPSfinder are listed in Table 7

Approximately23 mL per zone is usually sufficient, depending on the size of the area being treated