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Keywords: Metformin, Vitamin B 12 deficiency, Diabetes mellitus, Vitamin B12, Type 2 diabetes mellitus Core Tip: In the last 20 years, there was increasing evidence of the presence of vitamin B12 deficiency among metformin-treated diabetic patients

When this happens, muscle fibers stay contracted, being unable to relax, restricting movement and significantly impacting the quality of your life

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NAD+ serves as an essential coenzyme in the mitochondrial electron transport chain and as a critical substrate for sirtuins, PARPs, and CD38-type enzymes involved in DNA repair, stress resistance, and metabolic homeostasis