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Policy Note: This article is a slightly abridged version of a review first published in the Cleveland Clinic Journal of Medicine (2025;92(3):147-151)

Muscle PARP1 inhibition extends lifespan through AMPKalpha PARylation and activation in Drosophila

126 TrachoothamD.ZhouY.ZhangH.DemizuY.ChenZ.PelicanoH.et al (2006)

In regard to hypothalamus-pituitary-adrenocortical (HPA) axis function, there was a significant decrease in plasma ACTH (t = 2.601, p = 0.021) and cortisol (t = 3.091, p = 0.008) concentration at E9 compared to BL

We also generated a strep-MBP-ROXY9-CPYC derivative in order to ask the question whether the class III GRX-specific second cysteine might interfere with catalytic activity