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Some individuals with methylmalonic acidemia with homocystinuria, whose signs and symptoms begin later, in life develop subacute combined degeneration of the spinal cord resulting in numbness and weakness in the lower limbs, and difficulty walking which can lead to frequent falls

Ammonia is released as a result of the transformation of glutamine into glutamate [78, 79]

There are three main phenotypes of primary carnitine deficiency (PCD): the fatal neonatal form, the severe infantile hepatocardiomuscular form and the most common (and mildest) myopathic form, characterised by exercise-induced muscle pain, weakness and myoglobinuria

H2S deficiency precedes the onset of high blood pressure

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