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The upstream regulation of GPX4 mainly include transcription factors such as Nrf2 (Dodson et al., 2019), MYB (Hao et al., 2017), Tfap2c (Alim et al., 2019), Sp1 (Alim et al., 2019), Lipocalin 2 (LCN2) (Chaudhary et al., 2021), mTORC1 (Saxton and Sabatini, 2017

doi: 10.1097/WNF.0000000000000246

The entire transformation procedure was repeated to delete both copies of GDH alleles

For consistent cellular repletion, a delivery mechanism that bypasses intestinal degradation is essential