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Surprisingly, CD38 bound to the plasma membrane has its catalytic site located on the extracellular domain of the cell, which poses theoretical difficulties for understanding how CD38 generates cADPR in the cytoplasm, where it should be available to interact with calcium channels

Available at: ClinicalTrials.gov
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[Google Scholar] [27].Goldwater LJ, Mercury: A History of Quicksilver, York Press, Baltimore, 1972

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