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Studies have demonstrated that SOD2 inhibits signaling pathways such as Janus kinase/signal transducer and activator of transcription (JAK/STAT) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), thereby impeding vascular senescence and delaying the progression of vascular disease [121]

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KD efficiency at the gene level was calculated pseudobulking each supervised cell type per TF per gene per individual after collapsing all active sgRNAs targeting the same gene

Large Genomic Regions Identified With Multiple Methods We also found genomic regions with clusters of SNPs and genes that showed linkage for Cd tolerance and leaf accumulation of Hg, which aligned with regions also identified using population genomics methods