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[,] Oxidative stress is also significantly involved in schizophrenia, and comprehensive studies have shown a connection between both positive and negative symptoms and damage caused by oxidative stress

As for non-small cell lung cancer (NSCLC), mutations in the epidermal growth factor receptor render these cancer cells highly dependent on cysteine supply

Lymphoid compartment T Cells in atherosclerosis T cells are important adaptive immune regulators of atherosclerosis, demonstrating both atheroprotective and proatherogenic effects depending on the specific T cell subset

NRF2, a superstar of ferroptosis

Secondly, since cardiomyocytes are easily affected by free iron overload, the release of excess free iron during ferroptosis would result in up-regulation of transferrin receptor (TFR) and down-regulation of ferritin, promoting cardiomyocyte cell death through mitochondrial VDAC2/3 or membrane lipid peroxidation through Fenton reaction to induce myocardial edema and dysfunction (Liu et al., 2018)