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Description
The delivery matters

Lyophilization (freeze-drying): Preserves integrity and extends shelf life
Hydroxocobalamin acts as a crucial cofactor in various metabolic processes, supporting the conversion of homocysteine to methionine, which is essential for DNA synthesis and cellular function
This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

Scientific Reports 10:16749