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Although far less common, long-term increases in free fatty acids and reduced short-chain fatty acid production can precipitate myocardial insulin-resistance [102] while ketone bodies can promote cardiac scarring and cell senescence [103]

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These findings align with previous research demonstrating the therapeutic potential of natural products like Cinnamaldehyde, Sarsasapogenin-AA13, Ginkgo biloba extracts, and active components of Andrographis paniculata in targeting these pathways for AD treatment [49, 89,90,91,92]