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Cadmium may accentuate inflammatory processes, which may in turn disrupt the HPA axis and trigger symptoms of ME/CFS (161, 162)

Fuchs BC, Perez JC, Suetterlin JE, Chaudhry SB, Bode BP

This vasorelaxation is mediated through actions on purinergic receptors, specifically adenosine receptors ( + regulates the activity of NADPH oxidase, a significant ROS source in vascular cells, thereby playing a key role in the modulation of vascular tone (Reid et al., 2018)

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress