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In the absence or inhibition of caspase-8 (8185) through genetic manipulation or caspase inhibitors (such as z-VAD) the interaction between RIPK3 and its substrate Mixed Lineage Kinase Like (MLKL) is promoted, which results in cell membrane disruption and cell death (86)

For example, to make a 1 mg/mL solution from a powder with 80% peptide content, a researcher must dissolve 1.25 mg of the powder in 1 mL of solvent to get a final concentration of 1 mg/mL of pure peptide

Our peptide calculator displays results in both mL and syringe units for easy reference

10.1016/j.jcf.2021.01.010 [DOI] [PubMed] [Google Scholar] 116.Griese M, Kappler M, Eismann C, Ballmann M, Junge S, Rietschel E, et al

Aging Cell 22, 2023