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These drugs have demonstrated effectiveness in lowering the incidence and development of breast, colorectal, cervical, and liver cancers by inducing apoptosis, limiting angiogenesis, and blocking metastasis in vitro and in vivo models (12, 44)

10.3390/ijms131113830 77 MatteraR.BenvenutoM.GigantiM

Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

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Nutrition and Cancer,47 (2), 126-130