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Taken together, FOXO4-DRI is able to remove the senescent cells in PDL9 chondrocytes, but its utility in promoting cartilage formation from the in vitro expanded chondrocytes needs further investigation
Conversely, an unbalanced gut microbial population can prevent the activation of Th17 cells at the expense of Th1, Th2, and Treg cell differentiation
In that setting, the first question is tolerance, not theoretical benefit
