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What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect

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10.1038/s41598-018-25157-6

This could be due to several factors such as curvature of the cerebellum, shape of the overlying bone and sinuses, tissue density, or its relatively weak mechanical attachment to the rest of the brain via three pairs of fiber bundles, which all could affect the proper anchoring of electrodes to the targeted region