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Mn overexposure also reduces glutamate receptor expression, NMDAR, in neurons in vitro and in vivo , potentially exacerbating glutamate-induced excitotoxicity (Wang et al., 2017
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Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR Jr

By calming the cellular environment, glutathione helps the innate immune system return to a less reactive, more balanced state
