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This occurred in the various models, i.e., amputation of the tail, leg [70,71], prolonged occlusion of the vein [38], anticoagulants or aspirin [70,71] or L-arginine (NOS-substrate, NO-system over-activity) [71] application, and organ perforation [69]

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Recently, studies have shown that APR-246 can exert additional effects, particularly through antagonizing the glutathione (GSH) and thioredoxin reductase system 4,5 , leading to increased reactive oxygen species (ROS)

Glutathione-based skin whitening injections work best for individuals with darker or uneven skin tones, though results may vary based on skin type and underlying pigmentation

2.8 Immunohistochemical assessment A immunohistochemical assessment involved antigen retrieval, blocking endogenous peroxidase with 3% H2O2 and 3% BSA for 30 min